BRAIN & BRAIN PET 2019 – Yokohama

INTRACRANIAL FLUIDS DYNAMICS ALTERATIONS AND CORTICAL THICKNESS

Alexandra Vallet1,2, Sylvie Lorthois1, Nicolas Chauveau2, Natalia Del Campo2, Laurent Balardy3, Patrice Peran2, Armelle Lokossou4, Olivier Baledent4, Pierre Payoux2, Eric Schmidt2,3.

  1. Inst. de Mecanique des Fluides de Toulouse UMR 5502, Toulouse, France
  2. TONIC UMR 1214, INSERM, Toulouse, France
  3. University hospital, Toulouse, France
  4. BIOFLOW EA 7516, Amiens, France

Objectives

The issue of cortical atrophy is important in normal aging and disease since it is associated with cognitive and physical impairments. Cortical atrophy is potentially a relevant biomarker for the early diagnosis of Alzheimer’s disease (AD).The vascular component is also an integral part of AD and other late-life neurodegenerative diseases. Abnormalities in blood flow appear before accumulation of abnormal proteins in AD. The occlusion of capillaries by neutrophils are significantly higher in AD animal models than control and reduction of those occlusions with an antibody increases both blood flow and cognitive capacities. Vascular alterations lead to hypoperfusion, oxidative stress and inflammation, which in turn lead to damage of neurons, glia and myelin, predominantly in the white mater.

Implication of vascular pathologies for gray matter remains unclear. A recent study showed that altered cerebral hemodyamics in asymptomatic carotid artery stenosis is associated with cortical thinning. However there is no proven link between vascular pathologies and cortical thinning. We propose to explore brain aging with a combined biomechanical and imaging approach in order to assess both fluid dynamics alterations and brain structural modifications.

We hypothesize that there is a link between altered cerebral hemodynamics and loss of cortical thickness during brain aging.

Methods

80 patients suspected of hydrocephalus were prospectively involved. All patients complain of gait alteration, urinary difficulties, mild apathy and ventriculomegaly on brain imaging. They underwent brain MRI with T1 weighted images to quantify cortical thickness and phase contrast images to measure arterial, venous and CSF velocities. Lumbar infusion test was also performed to gauge lumbar pressure, a surrogate marker of intracranial pressure (ICP), and CSF dynamics. The cortical volumetric segmentation was done by an automatic post-processing analysis with FREESURFER. Venous, arterial and CSF velocities were measured from PCMRI with BIOFLOWIMAGE software. ICP and CSF dynamics were extracted form infusion tests. Pearson correlations were calculated between cortical thickness and arterial, venous and CSF velocities, but also ICP and derived indices.

Results

Mean cortical thickness was positively correlated with mean ICP (r=0.48, p=0.001), ICP pulse amplitude (r=0.43, p=0.001), arterial flow (r=0.44, p=0.001), aqueductal CSF flow(r=046, p=0.001), but negatively correlate with venous flow (r=-0.44, p=0.001) 

Conclusions

We demonstrate that cortical thickness is correlated with arterial and CSF pulsatility. The causality is more complex; however the association between intracranial pulsatility and gray matter thickness suggests that there is a relationship between vascular alterations at the macroscale level and the pathobiology of cortical atrophy.

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