Research

 

Biomechanics of brain aging

The core of my research project relies on an original interdisciplinary approach to brain aging combining physical, biological and clinical approaches.

The objective is to use a physical model of the brain
– to interpret in vivo observations;

– to explore sub-millimeter phenomena that cannot be assessed by imaging alone;

– to extrapolate animal models observations up to human scale.

During brain aging we can observe modifications of the brain structure, micro-structure, mechanical properties and fluid dynamics. Modeling those processes should lead to better understand the underlying mechanisms in neurodegenerative diseases and ultimately provide a new, outside-the-box diagnostic approach relevant for preventive strategies and patient follow up.

Ongoing Projects

project planning steps

2019

Develop a meso-scale model of the brain

In the context of the BRAINMICROFLOW project (PI S. Lorthois), the coupling between the vascular system, the CSF and the cerebral tissue at the mesoscale level will be described with a network approach.

2018

Demonstrate clinical relevance of biomechanical approach

In the context of the FLUIDBRAIN project (PI E. Schmidt), a simplified model of the CSF dynamics is used to interpret data from a cohort of 100 patients. Brain biomechnical properties appear to be significantly (p<0.05) associated with patients frailty degree (cognitive and physical impairment).

Host Institutions

I acknowledge the institutes that hosted my research and believed in the strong potential of the interdisciplinary approach of brain aging.

Funding opportunities for highrisk fundamental project in clinical research field are rare.

The results obtained are promising and I am constantly applying for new funding opportunities in order to pursue the project.