Biomechanics of brain ageing
My research project relies on an original interdisciplinary approach to brain ageing combining physical, biological and clinical approaches. It focuses on an aspect of the brain that has been neglected in previous researches about dementia: its pulsatile behaviour.
Focus: intracranial pulsatility
During brain ageing, we can observe modifications of the brain structure, microstructure, mechanical properties and fluid dynamics.
I am convinced that alteration of brain pulsatility reflects an accumulation of brain pathologies and can be used to analyse brain ageing.
Approach: use of mathematical models
My original approach is to use mathematical models based on fundamental physical laws
- to interpret in vivo observations;
- to explore sub-millimetre phenomena that cannot be assessed by imaging alone;
- to extrapolate animal models observations up to the human scale.
Analysis of brain pulsatility should lead to a better understanding of the underlying mechanisms in neurodegenerative diseases and ultimately provide a new, outside-the-box diagnostic approach relevant for preventive strategies and patient follow up.
Modelling techniques gallery
Previous and ongoing projects
I acknowledge the institutes that hosted my research and believed in the strong potential of the interdisciplinary approach of brain aging.
Funding opportunities for highrisk fundamental project in clinical research field are rare.
The results obtained are promising and I am constantly applying for new funding opportunities in order to pursue the project.