Short Biography

I am a researcher with interdisciplinary expertise motivated by the modelling of complex multi-scale multi-physics problems.

I acquired a solid background in applied mathematics and physics in a graduate engineering school and through a PhD in high energy density physics.

I spent 7 years of research in the field of radiative hydrodynamics, using complex multi-physics, multi-code simulations as well as analytical approaches to both design and interpret experiments on large laser facilities such as OMEGA and Laser Megajoule.

Willing to act for a concrete and direct social concern I considered building bridges between physics and medical research. A fruitful encounter with neurosurgeon Eric Schmidt and physicist Sylvie Lorthois convinced me that crossing the borders between disciplines is full of potential for getting new insights into the understanding of the human brain complexity.

In 2018, I started to dive into neuroscience and brain mechanics : what a fascinating topic, with so much uncovered mysteries ! I am currently building a research project about brain aging based on my expertise as a physicist.

Research experience



The core of  my research project relies on an original interdisciplinary approach to brain aging combining mechanical and clinical approaches.

  • 2018-present Biomechanical approach of brain aging

    ALZHEIMER'S PHYSICS RCN funded post-doctoral fellow at Mathematics department, University of Oslo - Oslo NO
    BRAINMICROFLOW ERC funded post-doctoral fellow at IMFT - Toulouse FR
    FLUIBRAIN post-doctoral fellow at INSERM ToNIC - Toulouse FR

  • 2014-2017 High energy density physics - Megajoule Laser facility

    CEA - Paris
    Semi-private research project - confidencial

  • 2011-2013 Hydrodynamics of inertial confinement fusion

    CELIA Bordeaux & LLE Rochester
    PhD project

  • 2011 Instabilities in inertial confinement fusion

    CEA - Paris
    Master 2 project

  • 2010 FE simulation of pelvic mobilities

    INSERM U703 / École Centrale de Lille LML-UMR 8107
    Master 1 project

Selected Publications

For a complete list of publications, please follow the link bellow or see my CV.

Assessment of Pressure-Volume Index During Lumbar Infusion Study: What Is the Optimal Method?

Acta Neurochir Suppl. 2021;131:335-338.
Alexandra Vallet , Laurent Gergelé , Emmanuel Jouanneau , Eric A Schmidt , Romain Manet
Publisher's website

Biomechanical response of the CNS is associated with frailty in NPH-suspected patients

Journal of Neurology
Alexandra Vallet, Natalia Del Campo, Emiel Hoogendijk, Armelle Lokossou, Olivier Balédent, Zofia Czosnyka, Laurent Balardy, Pierre Payoux, Pascal Swider, Sylvie Lorthois, Eric Schmidt
Publisher's website

Transient effects in unstable ablation fronts and mixing layers in HEDP

Physica Scripta, 91(7): 074005, 2016
J-M Clarisse and S Gauthier and L Dastugue and A Vallet and N Schneider
Publisher's website

Selected Awards

Merit award

2010 – Award for my study in biomechanics (INSERM, EC Lille) – 4000€

Oscar waquet prize

2011 – Award for being first ranked at the Ecole des Mines de Douai school – 2500 €

Best poster award

2012 – Fusion Science Center Award for Excellence in Poster Presentation

Best poster award

2014 – European Physical Society best poster award